The Uber platform allows you to drive wherever and whenever you want. But some time periods and areas of the city experience higher demand than others. Below are the times and places that are typically busy.
Times periods with high earnings

Monday–Friday morning: 6am – 9am
Monday–Friday evening: 6pm – midnight
Friday and Saturday nights: 10pm – 3am
Sunday: 10am – 5pm
For each time period, the biggest areas in the city are:
Monday-Friday morning
Manhattan Midtown, West/East Village, Upper East/West Side, Financial District, Williamsburg, Downtown Brooklyn, Park Slope

Monday-Friday evening
Manhattan Midtown, West/East Village, Financial District, Upper East/West Side, Williamsburg, Downtown Brooklyn

Friday & Saturday nights
Manhattan Midtown, West/East Village, Williamsburg, Financial District, Upper East Side

Sunday
Manhattan Midtown, West/East Village, Financial District, Upper East/West Side, Williamsburg, Downtown Brooklyn